ParkDB: a Parkinson’s disease gene expression database
نویسندگان
چکیده
Parkinson's disease (PD) is a common, adult-onset, neuro-degenerative disorder characterized by the degeneration of cardinal motor signs mainly due to the loss of dopaminergic neurons in the substantia nigra. To date, researchers still have limited understanding of the key molecular events that provoke neurodegeneration in this disease. Here, we present ParkDB, the first queryable database dedicated to gene expression in PD. ParkDB contains a complete set of re-analyzed, curated and annotated microarray datasets. This resource enables scientists to identify and compare expression signatures involved in PD and dopaminergic neuron differentiation under different biological conditions and across species. Database URL: http://www2.cancer.ucl.ac.uk/Parkinson_Db2/
منابع مشابه
Database tool ParkDB: a Parkinson’s disease gene expression database
UCL, Department of Cancer Biology, University College London, Gower Street, London, UK, Department of Medicine, Unit of Computational Medicine, Centre of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Department for Endocrinology, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, UK, CBM S.c.r.l., Baso...
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ورودعنوان ژورنال:
دوره 2011 شماره
صفحات -
تاریخ انتشار 2011